The major protein of pancreatic zymogen
granule membranes (GP2) is anchored via covalent bonds to phosphatidyl inositol.
Seven translocation negative cases demonstrated papillary architecture with arborizing vessels 4 cases, vacuolated tumor cells (4 cases), solid sheets of bland tumor cells with eccentrically placed nuclei (7 cases), and zymogen
granules (3 cases).
Bach1b contains both BTB and BZIP domains and mediates the regulatory role of heme in transcription of the zymogens
in zebrafish [17, 18].
TAFIa is produced from its zymogen
TAFI by cleavage at R92A93 by the thrombin/thrombomodulin complex .
Secondly, the released PPO exists as zymogen
in the hemolymph and must be activated by proteolytic cleavage [11, 20].
Co-localisation of zymogen
granules and lysosomes occur within the acinar cells and is seen in minutes of pancreatic injury.
Interaction Between Lipopolysaccharide and Intracellular Serine Protease Zymogen
, Factor C, from Horseshoe Crab (Tachypleus tridentatus) Hemocytes.
It also mimics ACC, sharing the granular cytoplasm, microvacuoles, and microcystic growth pattern of ACC but lacking the cytoplasmic basophilia characteristic of ACC owing to the presence of zymogen
granules [Figure 7].
They confirmed experimentally in vivo and in vitro that decreasing pH (acidifying) increases the sensitivity of the acinar cells to zymogen
As suggested by DNA sequences, MMP-9 shares homology with collagenase, which is secreted as zymogen
that can be activated by proteases or organic mercury compounds.
The acinar cells of the pancreas produce and transport a variety of chemical compounds called proenzymes which are stored in zymogen
granules that exit the body via the digestive system where the proenzymes are converted into active enzymes and assist in the digestion of fats, proteins, and carbohydrates.