By the cross-sectional diameter of large osteons, wall thickness, and cross-sectional diameter of large
Haversian canals located in perimedullary zones of the long bones studied, they exceed the same indices in subperiosteal zone.
(9) Unaffected areas of the jaw in patients with BRONJ have prominent trabecular structures and smaller and fewer
Haversian Canals. (10) Aminobisphosphonates (alendronate and pamidronate) also have an antiangiogenic effect, (3,4) which, while preventing metastatic disease to the bone, may play a role in the pathogenesis.
The rubbery matrix found in people deficient of cholecalciferol does not provide sufficient trabecular and collagenous support but instead hydrates and expands the bone, causing an outward pressure on the internal
Haversian canals and external periosteal covering, richly innervated with sensory pain fibres.