Encyclopedia

Inhibitor

Also found in: Dictionary, Medical, Acronyms, Wikipedia.
(redirected from NNRTI)

inhibitor

[in′hib·əd·ər]
(aerospace engineering)
A substance bonded, taped, or dip-dried onto a solid propellant to restrict the burning surface and to give direction to the burning process.
(chemistry)
A substance which is capable of stopping or retarding a chemical reaction; to be technically useful, it must be effective in low concentration.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.

inhibitor

A substance added to paint to retard drying, skinning, mildew growth, etc. Also see corrosion inhibitor, inhibiting pigment, drying inhibitor.
McGraw-Hill Dictionary of Architecture and Construction. Copyright © 2003 by McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Inhibitor

 

a circuit having m + n inputs and a single output, at which a signal can appear only when there are no signals on the m inputs (inhibiting). The other n inputs (principal) form one of the two logic connections, “AND” or “OR.” Inhibitors are used extensively in computers. They are very often understood to be a circuit having a single principal input and a single inhibiting input. A signal appears at the output of such a circuit when a signal is present on the principal input but there is none on the inhibiting input. Such an inhibitor is called an anticoincidence gate; its conventional representation is given in Figure 1.

Figure 1. Block diagram of an anticoincidence gate (inhibitor) with m — 1 and n 1:(A) principal input, (Q) inhibiting input, (Ga) anticoincidence gate

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
Mentioned in
References in periodicals archive
Hastalara Baslanan Antiretrovital Tedavi Rejimleri Antiretroviral Tedavi Rejimleri Sayi (%) 2 NRTI + INI 97 (49.5) 2 NRT + NNRTI 16 (8.2) 2 NRTI + PI 83 (42.3) NRTI: nukleozid revers transkriptaz inhibitoru, INI: integraz inhibitoru, NNRTI: nonnukleozid revers transkriptaz inhibitoru, PI: proteaz inhibitoru.
In primary analyses, women in the switch arm had significant improvements in total and LDL cholesterol but did not have a statistically significant improvement in VAT compared to women continuing an NNRTI or PI [40].
If the patient is on an NNRTI-based regimen, stop the NNRTI first and the NRTIs after 5-7 days (however, if the patient is in liver failure, stop all ART immediately).
Both schemes refer to the combination of 2 NRTI + NNRTI and require a lower daily intake of tablets, as shown in Table 1.
While 111 people (44%) were taking a protease inhibitor when they joined the study, 92 (36%) were taking a nonnucleoside reverse transcriptase inhibitor (NNRTI).
The drug, part of a category of medicines known as non-nucleoside reverse transcriptase inhibitors (NNRTIs), is said to work by blocking the virus' ability to replicate in the patient's blood.
Newer antiretrovirals, used for more treatment-experienced patients, are still in the registration process, such as the second-generation NNRTI etravirine (ETV) and the integrase inhibitor raltegravir (RLT).
In terms of antiretroviral drug regimens, HIV-2 is intrinsically resistant to non nuclesoside reverse transcriptase inhibitors (NNRTI) such as nevirapine and efavirenz and not all the protease inhibitors (PIs) provide good viral suppression (15).
Antiretroviral histories of the aging-up cluster often mirror those of adults who began treatment in the pre-HAART era with single or double nucleosides, then added a protease inhibitor (PI) or nonnucleoside (NNRTI) to a faltering antiretroviral duo and ended up with multiple resistance mutations and multiclass failure.
Bone densities were retested after 48 weeks of combination HIV therapy with a nonnucleoside reverse transcriptase inhibitor (NNRTI) and nucleoside reverse transcriptase inhibitors (NRTIs), or an NNRTI and a boosted protease inhibitor, or two NRTIs and a boosted protease inhibitor.
In return, Glaxo secures exclusive worldwide rights to IDX899, a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) drug in mid-stage Phase II clinical tests for HIV/AIDS that is suitable for once-a-day administration.
This review focuses on the new protease inhibitors (PI) and non-nucleoside reverse transcriptase inhibitors (NNRTI) that are currently available for clinicians to prescribe and explores their potential niche in antiretroviral treatment choices.
Copyright © 2003-2025 Farlex, Inc Disclaimer
All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.