neutrophil

[′nü·trə‚fil]

(histology)

A large granular leukocyte with a highly variable nucleus, consisting of three to five lobes, and cytoplasmic granules which stain with neutral dyes and eosin.

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Neutrophil

(also called polymorphonuclear neutrophil leukocyte, microphage), a type of white blood cell, or leukocyte, occurring in vertebrates and man. The diameter of a neutrophil ranges from 9 to 12 μ. The cytoplasm of these cells contains granules that attract both basic and acidic dyes, and this is why these leukocytes are called neutrophils.

A neutrophil is classified according to its degree of maturity: a metamyelocyte is a young neutrophil with an unsegmented nucleus, a rod neutrophil has a nucleus in the shape of a curved rod, and segmented, or filamented, neutrophils have segmented nuclei. Neutrophils are phagocytes that are capable of ingesting small foreign particles, including microbes. By elaborating hydrolytic enzymes, neutrophils can lyse dead tissue. Neutrophilia is an abnormal increase in the concentration of neutrophils in the blood. (SeeLEUKOCYTOSIS.)

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References in periodicals archive

Neutrophil migration in infection and wound repair: going forward in reverse.

The Effect of Hemodialysis on the Expression of CXCL8 and its mRNA in Neutrophils of the Patients with Chronic Renal Failure

In our study, although neutrophil counts of the study groups were similar, lymphocyte count was significantly lower in malignant thyroid nodule group than benign nodule and control groups resulting in elevated NLR.

Neutrophil to Lymphocyte Ratio is Useful in Differentiation of Malign and Benign Thyroid Nodules

Compared with a Barr body, which appears as a drumstick-shaped appendage of a nuclear lobe, (4) a Howell-Jolly body-like inclusion appears as a completely detached and densely basophilic inclusion in the cytoplasm of neutrophils. Howell-Jolly body-like inclusions are thought to represent a product of dysplastic granulopoiesis.

Howell-Jolly Body-Like Inclusions in Neutrophils of Patients With Myelodysplastic Syndrome: A Novel Correlation

Neutrophil migration to the brain tissue affected by ischemia has also been shown by histochemical methods.

Analysis of Neutrophil/Lymphocyte ratio and Thiol/Disulfide homeostasis parameters in patients admitted to the emergency department with ischemic stroke

Binary logistic regression analysis revealed that among variables that differed significantly between the lymph node positive and lymph node negative groups, only an increased neutrophil count was independently associated with LNI (OR 5.12, 95% CI 1.168-22.452; -=0.03) (Table 3).

Can Preoperative Complete Blood Count Parameters Be Used as Predictive Markers for Lymph Node Metastasis in Endometrial Carcinomas?

Our study also demonstrated that lower dose of PDX (1 ng or 10 ng) reduced total cell numbers in lung exudation, mitigated neutrophil infiltration and that the 1 ng PDX was more effective.

Protectin DX Exhibits Protective Effects in Mouse Model of Lipopolysaccharide-Induced Acute Lung Injury

So our approach is to take neutrophil cell membranes, which naturally have receptors to bind all these different types of cytokines, and use them to manage an entire population of inflammatory molecules," explained Zhang.

Researchers develop neutrophil 'nanosponges' to cure arthritis

[4.] Brinkmann V, Zychlinsky A (2012) Neutrophil extracellular traps: Is immunity the second function of chromatin?

Formation of Neutrophil Extracellular Traps against Infection and During Inflammation: Boon or a Bane?

Numerous neutrophils were present within the cytoplasm of the malignant cells as well as in the surrounding stroma.

Significant Neutrophilic Emperipolesis in Squamous Cell Carcinoma

In May 2010, the patient presented with urinary tract infection (UTI) caused by Escherichia coli with an observed increase in the levels of neutrophil CD64.

Clinical Utility of Neutrophil CD64 to Detect Extrapulmonary Tuberculosis in Three Patients with Rheumatoid Arthritis Undergoing Treatment with Biologics