Although the adult skeletal muscle is composed of totally differentiated fibers, it preserves the ability to regenerate as a response to an injury and to modify its contractile and metabolic properties; thanks to
satellite cells residing in between the basal lamina and the plasmalemma, that are swiftly activated as a response to the appropriate stimuli.
Fibre type-specific
satellite cell response to aerobic training in sedentary adults.
Regarding estradiol's impact on exercise-induced muscle damage, one possible mechanism is its association with the myogenic activation of
satellite cells to assist with muscle repair and regeneration during recovery (Farup et al., 2014).
The mRNA expression level of Pax7, which is expressed in activation and proliferation state of
satellite cells, was significantly increased only in the nonPrecon group at 2 and 4 days after damaging ECC (Figure 3(b)).
Satellite cell activity in muscle regeneration after contusion in rats.
Culturing
satellite cells from living single muscle fiber explants.
Activated
satellite cells were observed separating from muscle fibers (Fig.
When the researchers injected old mice with GDF11, the population of
satellite cells increased, and the number of
satellite cells with severe DNA damage fell by a factor of 4.
Voluntary resistance wheel exercise during post-natal growth in rats enhances skeletal muscle
satellite cell and myonuclear content at adulthood.
In addition, the overexpression of anticancer genes cyclin-dependent kinase inhibitor, [p16.sup.INK4a], in
satellite cells irreversibly may affect their intrinsic regenerative and self-renewal capacities in sarcopenic muscles.
Macrophages enhance muscle
satellite cell proliferation and delay their differentiation.