Mentioned in

References in periodicals archive

Reaction of anti-OJ autoantibodies with components of the multi-enzyme complex of aminoacyl-tRNA synthetases in addition to isoleucyl-tRNA synthetase.

Partnering with these 20 tRNAs are 20 matching helper enzymes known as synthetases (aminoacyl-tRNA synthetases), whose job it is to load their partner tRNAs with the correct amino acid.

How Genes Were First Translated Into Proteins

Glutathione normally regulates its own biosynthesis by inhibiting [gamma]-glutamylcysteine synthetase, the enzyme catalyzing the first step in the [gamma]-glutamyl cycle.

A case of severe glutathione synthetase deficiency with novel GSS mutations

The following antibodies were assayed: antiOJ (anti-isoleucyl) antibody against isoleucyltRNA synthetase; anti-EJ (anti-glycyl) antibody against glycyl-tRNA synthetase; anti-threonyltRNA synthetase (anti-PL7) antibody against threonyl-tRNA synthetase; anti-alanyl-tRNA synthetase (anti-PL-12) antibody against alanyltRNA synthetase; and anti-Jo-1 antibody against histidyl-tRNA synthetase.

The Association of Anti-Aminoacyl-Transfer Ribonucleic Acid Synthetase Antibodies in Patients With Rheumatoid Arthritis and Interstitial Lung Disease

(20) Even within the group of ARS, patients with anti-Jo-1 autoantibodies seem to fare better than do those with other anti-tRNA synthetase autoantibodies, such as anti-PL-12, predominantly because of worse pulmonary outcomes.

Pulmonary Pathologic Manifestations of Anti-Alanyl-tRNA Synthetase (Anti-PL-12)-Related Inflammatory Myopathy

Ammonium is assimilated into amino acids in a process that is catalyzed mainly by the GS-GOGAT (glutamine synthetase and glutamate synthase) pathway.

Expression Analysis of Nitrogen Metabolism-Related Genes Reveals Differences in Adaptation to Low-Nitrogen Stress between Two Different Barley Cultivars at Seedling Stage

Interestingly, amongst the seven genes that have been identified to cause the disease, most have housekeeping functions, including small heat shock proteins (sHSP) (dHMN-II); glycyl tRNA synthetase (GARS) (dHMN-V); Berardinelli-Seip congenital lipodystrophy (BSCL2) (dHMN-V); immunoglobulin [micro]-binding protein-2 (IGHMBP2) (dHMN-VI); dynactin (DCTN1) (dHMN-VII); and senataxin (SETX) (dHMN) with pyramidal tract signs.

Glycyl tRNA Synthetase (GARS) Gene Variant Causes Distal Hereditary Motor Neuropathy V

To the Editor: Mutations in the mitochondrial alanyl-tRNA synthetase 2 gene ( AARS2 ) have been recently found to lead to chronic progressive leukodystrophy or infantile cardiomyopathy.

Leukodystrophy without Ovarian Failure Caused by Compound Heterozygous Alanyl-tRNA Synthetase 2 Mutations

Some promise in the treatment of keloid has been offered by 5-fluorouracil (5-FU), which is a potent inhibitor of thymidylate synthetase and interferes with pyrimidine metabolism, thus DNA synthesis is blocked.6 It was found that when used alone, 5-FU did not perform better than steroid.

Comparison of efficacy of intralesional 5-fluorouracil plus triamcinolone acetonide versus intralesional triamcinolone acetonide in the treatment of keloids

Asparagine synthetase (ASNS) is an expression status present in various tumour types, such as leukaemia, lymphoma and pancreatic cancer.

Erytech publishes positive phase 2b data for eryaspase, a treatment for metastatic pancreatic cancer