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For example, mutations in the E3 ligase Parkin occur in Autosomal recessive Parkinson's disease.

Mitochondrial quality control: decommissioning power plants in neurodegenerative diseases

Roman et al., "Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2, 4-dione inhibitors of MurD ligase," Journal of Medicinal Chemistry, vol.

Catalyst-free synthesis of highly biologically active 5-arylidene rhodanine and 2,4-thiazolidinedione derivatives using aldonitrones in polyethylene glycol

In ERAD, the protein region ubiquitinated varies depending on the substrate and the E3 ubiquitin ligase involved.

A novel peptide-based SILAC method to identify the posttranslational modifications provides evidence for unconventional ubiquitination in the ER-associated degradation pathway

While the E3 ligase Ube3A is widely known for its role in the Prader-Willi and Angelman syndromes, rare forms of mental retardation, Ube3A has also recently been implicated in regulation of dendritic arbor growth in fruit flies.

Breaking it down: the ubiquitin proteasome system in neuronal morphogenesis

Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy.

Grail suppresses stress-induced apoptosis and colony formation in oral cancer cells

The resistance level (MICs, 4->256 mg/mL) in vanB is lower than VanA and is attributed to VanB ligase enzyme that converts D-Ala-D-Ala to D-Ala-D-Lac, perhaps due to less substitution.28 The genes of VanB gene cluster are designated as VanHB, VanXB, VanYB, VanRB, and VanSB.

Vancomycin resistant Enterococci: A brief review

E3 ubiquitin ligase NEDD4-1 plays a proto-oncogenic role in tumors through regulating the tumor suppressor PTEN expression by ubiquitination and causing its proteasomal degradation and/or nuclear translocation.[5],[12] Recent studies have found that monoubiquitination of PTEN by NEDD4-1 promotes nuclear accumulation, and polyubiquitination of PTEN inducing its degradation in the cytoplasm, but the concrete mechanism is still unclear.

Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma

Zhao, "Ubiquitin E3 ligase LNX2 is critical for osteoclastogenesis in vitro by regulating M-CSF/RANKL signaling and Notch2," Calcified Tissue International, vol.

Deubiquitinating Enzymes and Bone Remodeling

TNFAIP3, also known as A20, is an ubiquitin-editing enzyme, which has dual roles in ubiquitin ligase and deubiquitinase activity.

Whole Exome Sequencing and Molecular Modeling of a Missense Variant in TNFAIP3 That Segregates with Disease in a Family with Chronic Urticaria and Angioedema

Hbo1 is an atypical ubiquitin E3 ligase for ER[alpha].

Intrinsic ubiquitin E3 ligase activity of histone acetyltransferase Hbo1 for estrogen receptor [alpha]

Intrinsic ubiquitin E3 ligase activity of histone acetyltransferase Hbol for estrogen receptor [alpha] Masayoshi Iizuka, Takao Susa, Mimi Tamamori-Adachi, Hiroko Okinaga and Tomoki Okazaki Communicated by Takao Sekiya, m.j.a.

Proceedings at the 1110th general meeting