Angiogenesis inhibitors often cause tumor vessels to regress resulting in vessel normalization.
McDonald, "Controlling escape from
angiogenesis inhibitors," Nature Reviews Cancer, vol.
Papai et al., "Pazopanib, a multikinase
angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancersoft tissue and bone sarcoma group (EORTC Study 62043)," Journal of Clinical Oncology, vol.
But new research suggests certain
angiogenesis inhibitors may actually promote the growth of tumours.
Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific
angiogenesis inhibitor 1 (BAI1).
Hirata, "Inhibition of liver metastasis of human pancreatic carcinoma by
angiogenesis inhibitor TNP-470 in combination with cisplatin," Japanese Journal of Cancer Research, vol.
Efficacy and toxicity of the
angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma.
The two bevacizumab arms also had similar progression-free survival: 4.8 months when the
angiogenesis inhibitor was combined with chemotherapy and 4.4 months when it was used with erlotinib.
He is now being treated with an
angiogenesis inhibitor in the hope that the tumor will not recur.
PTK/ZK is a novel, once daily oral
angiogenesis inhibitor designed to target the tumor blood vessels slowing tumor growth and spread.
(NASDAQ: REGN), Tarrytown, N.Y., has initiated a Phase I clinical trial that is designed to assess the safety and tolerability of the company's VEGF Trap, a potent
angiogenesis inhibitor, in patients with solid tumor malignancies and patients with non-Hodgkin's lymphoma.