Fixed drug eruption to quinine: a case report and review of the literature.
Fixed drug eruption (FDE), a unique type of cutaneous adverse drug reaction (ADR), was first described by Bourns in 1889 and later by Brocq as "eruption erythemato-pigmentee fixe".
TMP/SMX is a known cause of
fixed drug eruptions and other rare but potentially serious adverse drug reactions, such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and bone marrow suppression (4).
Key words: Drug eruptions, urticaria,
fixed drug eruption, sulfonamides.
AGEP: acute generalized exanthematous pustulosis; DRESS: drug reaction with eosinophilia and systemic symptoms; GBFDE: generalized bullous
fixed drug eruption; IVIG: intravenous immunoglobulin; SJS: Stevens-Johnson syndrome; TEN: toxic epidermal necrolysis; TNF: tumor necrosis factor.
The most common cutaneous ADR seen was
fixed drug eruptions (FDE), (29.3%), [Figure 1] followed by urticaria (20.7%) and maculopapular rash.
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Fixed drug eruptions can occur in the genital region, but the patient had neither bullous nor ulcerated eruptions (as one would expect with this condition).
Fixed drug eruption with ornidazole having cross-sensitivity to secnidazole but not to other nitro-imidazole compounds: a case report.
Fluconazole induced
fixed drug eruption: a rare offender.
Rosen cited the risks of gastrointestinal side effects, overgrowth of gram-negative microbes,
fixed drug eruptions and other rare allergic reactions, and dyschromia.
Differential diagnoses other than EM major include staphylococcal scalded skin syndrome (SSSS), linear immunoglobulin A (IgA) bullous dermatosis, acute graft-versus-host disease (GVHD), and generalized bullous
fixed drug eruption (GBFDE).
There were 2 cases of
fixed drug eruption, one case of Steven-Johnson syndrome and one patient of idiosyncratic reaction to methotrexate.