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Inhibitor

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inhibitor

[in′hib·əd·ər]
(aerospace engineering)
A substance bonded, taped, or dip-dried onto a solid propellant to restrict the burning surface and to give direction to the burning process.
(chemistry)
A substance which is capable of stopping or retarding a chemical reaction; to be technically useful, it must be effective in low concentration.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.

inhibitor

A substance added to paint to retard drying, skinning, mildew growth, etc. Also see corrosion inhibitor, inhibiting pigment, drying inhibitor.
McGraw-Hill Dictionary of Architecture and Construction. Copyright © 2003 by McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Inhibitor

 

a circuit having m + n inputs and a single output, at which a signal can appear only when there are no signals on the m inputs (inhibiting). The other n inputs (principal) form one of the two logic connections, “AND” or “OR.” Inhibitors are used extensively in computers. They are very often understood to be a circuit having a single principal input and a single inhibiting input. A signal appears at the output of such a circuit when a signal is present on the principal input but there is none on the inhibiting input. Such an inhibitor is called an anticoincidence gate; its conventional representation is given in Figure 1.

Figure 1. Block diagram of an anticoincidence gate (inhibitor) with m — 1 and n 1:(A) principal input, (Q) inhibiting input, (Ga) anticoincidence gate

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
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References in periodicals archive
"Reverset appears to be an excellent addition to our armamentarium of nucleoside reverse transcriptase inhibitors. It is well tolerated and active against virus with various mutations," he said.
However, while we know resistance can slow this virus down--we all know resistant virus can win; look at what happened in the era of treating with just nucleoside reverse transcriptase inhibitors (NRTIs) and the ongoing deaths from uncontrolled HIV.
Newer drugs are selecting for different types of resistance, especially in nucleoside reverse transcriptase inhibitors (NRTIs), so that there may not be large numbers of thymidine analog mutations (TAMs) developing in patients who have started therapy in recent years.
The randomized study of 122 patients with HIV added a protease inhibitor to a standard regimen of two nucleoside reverse transcriptase inhibitors and one nonnucleoside reverse transcriptase inhibitor for 62 patients who continued the induction regimen for 24-32 weeks in order to lower viral load to less than 50 copies/mL.
Also, among patients on multiple nucleoside reverse transcriptase inhibitors, platelet counts of less than 99,000/m[m.sup.3] (OR 2.40), creatinine greater than 1.5 times the upper limit of normal (OR 2.60), and use of concomitant hepatotoxic medications (OR 1.46) were associated with severe hepatotoxicity.
Surprisingly, support for this notion has come from testing the effect of removing single drugs from a failing regimen--in particular, nucleoside reverse transcriptase inhibitors (NRTIs).
The most common resistance was to nucleoside reverse transcriptase inhibitors (6.2% of specimens).
Each dose of Trizivir is a fixed-dose combination of Ziagen (abacavir/ABC), Retrovir (zidovudine/AZT), and Epivir (lamivudine/3TC), three nucleoside reverse transcriptase inhibitors (NRTIs) already approved by FDA.
Eviplera combines Gilead's Truvada, a fixed-dose combination of the two nucleoside reverse transcriptase inhibitors emtricitabine 200 mg and tenofovir disoproxil 245 mg, and Tibotec Pharmaceuticals' rilpivirine 25 mg, marketed by Janssen-Cilag International NV as Edurant.
In addition, ZDV and 3TC caused fewer adverse effects than combinations with different nucleoside reverse transcriptase inhibitors, didanosine (ddI) and stavudine (d4T).
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