Moderate-to-severe disruption in cellular arrangement of organ of corti, hydropic and vacuolar degeneration, loss of inner and
outer hair cells, chromatolysis in spiral ganglion cells, cytoplasmic and nuclear condensation, reduction in number of nuclei and neurons, irregular satellite cells, and hydropic and vacuolar degeneration in stria vascularis in groups 2 (Figure 1-2) and 3.
Santos-Sacchi, "Reversible inhibition of voltage-dependent
outer hair cell motility and capacitance," The Journal ofNeuroscience, vol.
In our study, we used SEM to show ototoxicity-related
outer hair cell damage.
Type 2 diabetes alters the functional status of
outer hair cells in the cochlea.
The main site of damage is the
outer hair cells in the basal turn of the cochlea, where aminoglycosides are received from the lysosomes of the cells' cytoplasm, which leads to the local formation of toxic free radicals and finally to hair cell apoptosis.
The Table summarizes the COMP-VA clinical objectives pertinent to identifying and monitoring changes in hearing and
outer hair cell function (objectives 1-4, listed above).
It has been indicated that the most affected cells are the
outer hair cells. At first, exposure to sound, the strength of hairs is affected which causes curvature disorders.
Permanent threshold shifts are a result of the swelling and deforming of
outer hair cells and alterations in endoplasmic reticulum.
Ashmore, "Cochlear
outer hair cell motility," Physiological Reviews, vol.
Platinum compounds damage the stria vascularis (columnar epithelium with capillaries which secretes endolymph in the scala media) and cause
outer hair cell death beginning at the basal turn of the cochlea.
OAEs are closely related to the
outer hair cell function.