(14,15,33)
Stem cell factor is produced by fibroblasts, epithelial cells, and even by mast cells themselves and appears to be important in the development, activation, and upregulation of mature mast cells and to the induction of mast cell degranulation.
"
Stem cell factor is a key player" in liver regeneration, says Neil D.
In our experiment, stage X avian blastoderm cells with stem cell morphology and epitope profiles could be maintained with stem-like characteristics for a long term in vitro with the support of the DF-1 feeder and basic culture medium supplemented with only three cytokines: human basic fibroblast growth factor (hbFGF), mouse
stem cell factor (mSCF), and human leukemia inhibitory factor (hLIF).
The growth factor
stem cell factor, which stimulates mast cell development, was thought to be essential for the formation of mast cells.
The combination of granulocyte colony-stimulating factor and
stem cell factor significantly increases the number of bone marrow-derived endothelial cells in brains of mice following cerebral ischemia.
Briefly, the harvested cells were filtered through a 40 [micro]m cell strainer, centrifuged at 3000 rpm for 7 minutes, and resuspended in complete culture medium of Dulbecco's Modified Eagle Medium (DMEM) supplemented with 10% fetal bovine serum (FBS), 1% of Pen-Strep, 100 ng/mL
stem cell factor (SCF), 10 ng/mL Interleukin-6 (IL-6), and 5 ng/mL Interleukin-3 (IL-3).
Their findings point to a relationship between the cKit receptor found on mast cells and the transmembrane
stem cell factor (SCF) ligand found on metastatic breast cancer cells.
c-Kit, also known as CD117, is a transmembrane receptor for a growth factor, termed
stem cell factor and has an internal tyrosine component.
In 2002, Amgen granted ViaCell a non-exclusive worldwide license to
Stem Cell Factor (SCF), a novel growth factor developed by Amgen, for ex vivo therapeutic uses.
Other studies by the two research groups have now determined safe doses of a newer growth-factor product, human
stem cell factor, which is produced by genetically engineered bacteria.
We further investigated the roles of proliferation of epithelium and a possible stromal stem cell in induction of pulmonary PT by immunostaining for proliferating index (Ki-67) and thyroid transcription factor 1 (TTF-1) (11) and c-Kit antigen (a
stem cell factor receptor/mast cell growth factor receptor).
It was found that BMMSCs secrete a wide range of different cytokines/growth factors, including interleukins: IL-6, IL-7, IL-8, IL-11, IL-12, IL-14, IL-15, leukemia inhibitory factor (LIF), granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-SCF), Flt-3 ligand (FL), and
stem cell factor (SCF) [51].