In this study, the TRP channel agonists capsaicin, RN1747, and
arachidonic acid stimulated bioluminescence in L.
As an advantage, licofelone has no gastric toxicity when compared to the selective inhibitor drugs that take role in both
arachidonic acid pathways (Narayanan et al., 2007).
Platelets do not express 5-LO but express high levels of the 12-LO enzyme which is responsible for the conversion of
arachidonic acid into 12-hydroxyeicosatetraenoic acid (12-HETE), an inflammatory lipid mediator implicated in vascular permeability.
Hereby, it has to be emphasized that in all cases
arachidonic acid is first transformed to unstable precursor intermediate molecules ending up to many "S" conformations after aspirin treated COX-2 [30,41].
The formation of [PGE.sub.2] from
arachidonic acid requires both COX and PGE synthase.
Efficacy and safety of
arachidonic acid for treatment of Schistosoma mansoni-infected children in Menoufiya, Egypt.
In our study PUFA was of great interest as most of the long chain fatty acid cannot be synthesized easily by human body like eicosapentaenoic acid (EPA; 20:53)
arachidonic acid (AA; 20:46) and docosahexaenoic acid (DHA; 22:63).
Among the physiological activators of platelet, thromboxane A [sub]2 (TXA [sub]2 ) is the primary one which is conversed from
arachidonic acid in the platelets and catalyzed by cyclooxygenase (COX).
Lipoxins (such as lipoxin A4 and lipoxin B4) are unique structures derived from
arachidonic acid that have potent actions in vivo and in vitro (Figure-1).
The EPA and DI-IA of omega-3 fatty acids become prostaglandins, while omega-6 fatty acids include
arachidonic acid (AA), which moves through the pathway to become a thromboxane.